解剖学和形态学
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abstract::The calcium (Ca(2+))-sensing receptor (CaR) belongs to family C of the G-protein coupled receptors (GPCRs). The receptor is activated by physiological levels of Ca(2+) (and Mg(2+)) and positively modulated by a range of proteinogenic L-alpha-amino acids. Recently, several synthetic allosteric modulators of the recepto...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907781695982
更新日期:2007-09-01 00:00:00
abstract::Animal behavioural profiles are commonly employed to investigate new therapeutic agents to treat anxiety disorders as well as to investigate the mechanism of action of anxiolytic drugs. However, many clinically important symptoms of anxiety can not be modelled directly in animals. Human models of anxiety should bridge...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907780077114
更新日期:2007-03-01 00:00:00
abstract::In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acety...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907780866901
更新日期:2007-01-01 00:00:00
abstract::Peripheral neuropathies are a heterogeneous group of diseases affecting peripheral nerves. The causes are multiple: hereditary, metabolic, infectious, inflammatory, toxic, traumatic. The temporal profile includes acute, subacute and chronic conditions. The majority of peripheral neuropathies cause mainly muscle weakne...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015906778019536
更新日期:2006-07-01 00:00:00
abstract::Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR)...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015906776359586
更新日期:2006-04-01 00:00:00
abstract::Although originally proposed as a subtype of opioid receptors, the sigma receptor is now confirmed to be a non-opioid receptor that binds diverse classes of psychotropic drugs. Sigma receptors are subdivided into two subtypes, sigma-1 and sigma-2. The sigma-1 receptor is a 25-kDa protein possessing one putative transm...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015905774322516
更新日期:2005-10-01 00:00:00